Yuan-Jyue Chen

À propos

I am a senior research scientist at Microsoft Discovery Quantum (Redmond), specializing in molecular biology and AI for science. I am also an affiliate professor at the Paul G. Allen School of Computer Science and Engineering, University of Washington (opens in new tab).

My career began with pioneering work in DNA computing and DNA Storage, building on a solid foundation in molecular and synthetic biology to engineer complex biological systems. This experience honed my ability to integrate systematic methodologies with creative problem-solving, consistently pushing the boundaries of biotechnology.

At Microsoft Research AI for Science, I have led evaluation efforts for the Science Foundation Model (SFM) across domains including small molecules, proteins, DNA/RNA, and materials. I have also spearheaded fine-tuning projects for peptide–MHC binding prediction, bridging deep biological insight with cutting-edge AI.

I received my PhD in Electrical Engineering from University of Washington in 2015, and I am an alumni of the University of Washington’s Seelig Lab (opens in new tab).  My PhD project was a collaboration between the biological computation research group at MSR Cambridge and Caltech. I came to Microsoft Research as a postdoc in 2015 and became a researcher in the DNA storage group in 2017.